What analytical method is identified for isocyanates?

High-performance liquid chromatography (HPLC) with a fluorescence detector is particularly suited for the analysis of isocyanates due to the inherent chemical properties of these compounds. Isocyanates can be difficult to analyze directly because they are highly reactive and can form adducts with moisture present in the air or solvents. When using HPLC, isocyanates are often reacted with an appropriate derivatizing agent to form a stable product.

The use of fluorescence detection is advantageous because it allows for highly sensitive detection of isocyanate derivatives. This sensitivity is crucial, as isocyanates are usually present in very low concentrations in air or workplace environments, making it essential to employ a method that can detect even trace amounts. The process of derivatization followed by HPLC enables the separation of these compounds from potential interfering substances and enhances the overall detection limits.

While gas chromatography and mass spectrometry are powerful analytical techniques, they may not offer the same sensitivity and stability for isocyanate detection in certain contexts. Infrared spectroscopy can identify functional groups, but it may not provide the specificity and quantification needed for precise measurements of isocyanate levels. Thus, HPLC with fluorescence detection stands out as the preferred and effective method for analyzing