What is a main toxicological effect of copper?

Copper is primarily known for its toxicological effect of causing metal fume fever, which is a condition associated with the inhalation of copper fumes produced during processes such as welding or melting metals that contain copper. This effect arises due to the body's reaction to the copper particles, leading to flu-like symptoms, including fever, chills, and respiratory issues. While copper can cause various effects depending on the exposure route and dose, the specific association with stored copper in the body leading to metal fume fever highlights its significance as a pulmonary irritant and systemic toxin.

Skin irritation and pulmonary edema are not the primary toxicological effects associated with copper itself. Similarly, severe headaches can result from various health issues or exposures but are not directly linked to copper toxicity. Thus, the focus on metal fume fever as a specific and recognized effect of copper inhalation underscores its importance in the field of industrial hygiene and toxicology, particularly in contexts where exposure to copper fumes is a concern.