Which of the following chemicals is known for having systemic effects when absorbed through the skin?

The correct answer is lead acetate. Lead acetate is a chemical compound that can be absorbed through the skin and is known for its systemic toxic effects on the body. When absorbed, lead acetate can interfere with various physiological functions, particularly affecting the nervous system, and can lead to widespread health problems including neurological deficits, anemia, and other systemic issues.

Skin absorption is a critical concern with lead acetate, especially in industrial settings or situations where skin contact is possible, making it crucial for industrial hygienists to implement appropriate safety measures.

On the other hand, TNT (trinitrotoluene), while hazardous and causing toxic effects primarily through inhalation or ingestion, is not notably absorbed through the skin to cause systemic effects. Asbestos affects primarily through inhalation, leading to respiratory diseases rather than skin absorption. Carbon monoxide, while dangerous and systemically acting through inhalation, does not pose risks via skin absorption. Understanding the specific routes of exposure for different chemicals assists in assessing risk and implementing effective safety protocols in industrial hygiene practices.