Which type of cancer is associated with exposure to 1,3-butadiene?

1,3-butadiene is classified as a human carcinogen, and its association with blood and lymphatic cancers stems from research indicating that it can lead to hematological malignancies, particularly leukemias and lymphomas. Studies have demonstrated that occupational exposure to 1,3-butadiene is linked to an increased risk of these types of cancers due to its metabolization in the body, which can result in the formation of DNA-damaging compounds.

Blood and lymphatic cancers are particularly susceptible because the blood-forming tissues, such as bone marrow and lymph nodes, are affected by undesirable changes caused by the exposure to this chemical. In contrast, although other cancers like breast, skin, and lung cancers are associated with various other environmental and occupational risks, they have not been established as directly linked to 1,3-butadiene in the same manner as blood and lymphatic cancers. This distinction underscores the specific toxicity of 1,3-butadiene to the hematological systems.